Testa Challenge 2020

The Testa Challenge 2020 bioprocess workflow – specifications

A start to finish bioprocess where a protein, a domain antibody fragment (dAb) was produced and purified.

Process outline:

Domain antibody fragment (dAb) production in E.coli in a single-use stirred-tank 50L bioreactor

Release of dAb to periplasm through heat treatment

Clarification and concentration of dAb using cross flow filtration

Purification of dAb using affinity and multimodal chromatography

Scitara

Scitara provides a digital platform that enables seamless, automated data exchange across laboratory instruments and software, improving productivity and data integrity.

Their solution eliminates manual steps in lab workflows, ensuring compliance and accelerating scientific discovery.

By streamlining data flow in regulated environments like pharma and biotech, Scitara supports faster innovation and enhances collaboration between research, development, and manufacturing teams.

atSpiro

atSpiro delivers a real-time gas analysis technology designed for advanced monitoring in biopharmaceutical manufacturing.

Their product continuously tracks key metabolic indicators during cell culture, enabling optimized process control without interrupting production.

This non-invasive approach supports faster development of biologics, enhances batch-to-batch consistency, and reduces production costs, ultimately contributing to more efficient and scalable bioprocessing.

Freesense

Freesense delivers a wireless sensor and modeling platform that provides full-volume insight into fermentation processes.

Their patented flow-following sensors enable real-time measurement of key parameters inside bioreactors. By offering deep process understanding, Freesense helps pharmaceutical and biotech companies optimize fermentation efficiency, reduce variability, and accelerate scale-up—bringing greater control and consistency to biologics manufacturing.

Argus Eye

Argus Eye offers a compact optical sensor system that enables real-time, in-line particle monitoring in bioprocesses.

Their patented light-scattering technology detects changes in particle size and concentration, providing early warnings of process deviations.

This supports better process control, increased efficiency, and improved product quality in the production of biologics and cell-based therapies.

UNIBAP

UNIBAP provides intelligent automation solutions using AI and space-grade computing for industries requiring high reliability.

Their platform combines advanced machine vision and edge computing to automate complex tasks in manufacturing, quality control, and space operations.

This improves operational efficiency and enables autonomous decision-making in environments where real-time performance and robustness are critical.

IS-Instruments

IS-Instruments specializes in advanced optical technologies for real-time chemical analysis using Raman spectroscopy.

Their robust instruments provide detailed molecular information without sample preparation, enabling in-line process control.

Designed for demanding industrial environments, their solutions help reduce production errors, improve safety, and accelerate development in pharmaceuticals, chemicals, and energy sectors.